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As part of this response, ANP stimulates lipolysis in adipocytes through the natriuretic peptide receptor-A (NPR-A) (109) and cyclic GMP (cGMP)/Protein kinase G (PKG) pathway to phosphorylate HSL and PLIN1 (110) (Figure 2)

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Metabolomic assessment reveals alteration in polyols and branched chain amino acids associated with present and future renal impairment in a discovery cohort of 637 persons with type 1 diabetes